Angela Poole

Precision nutrition refers to the quest to determine dietary recommendations for each individual to help them live their best (healthiest) life. Over the years, nutritional scientists have observed that people react differently to the same food. For example, some people’s blood glucose will rise higher if they eat ice cream than if they eat bananas. Surprisingly, for other people, that may not be the case. Which category do you fit into? How do we determine that??? The reasons for this variability are believed to include genetics and gut microbiota. Understanding all of the factors that affect this variability will enable us to make personalized recommendations about what each person should eat to avoid developing conditions such as type 2 diabetes, hypertension, and obesity.

Our goal is to elucidate the interactions between host genetics, dietary intake, and gut microbes in order to benefit host health. Our current projects focus on (1) optimizing dietary fiber intake to prevent diabetes and hyperlipidemia and (2) identifying factors underlying pathogenic biofilm formation in the mouth. Our research is interdisciplinary; we combine knowledge from genetics, nutrition, physiology, microbiology, and computational biology. Our findings could help to develop a systems biology approach to precision nutrition to assist in treating metabolic disorders or decreasing disease risk.

• NS 4010: Empirical Research