Computational Immunogenomics Approaches for Large-Scale Analysis of Adaptive Immune Systems
Adaptive immune responses rely on antibodies and T-cell receptors, which are generated through somatic V(D)J recombination rather than being fully encoded in the germline genome. This process targets the immunoglobulin (IG) and T-cell receptor (TCR) loci, composed of V, D, and J genes that serve as templates for assembly of adaptive immune receptors. While the diversity of expressed antibodies and TCR repertoires is well characterized, the diversity of germline IG and TCR loci and their impact on immune function remain poorly understood.
