Assistant Professor, Molecular Biology and Genetics
Brooks Crickard is an Assistant Professor in the Department of Molecular Biology and Genetics.
- PhD Pennsylvania State University
The research focus of the Crickard laboratory is to understand the mechanisms by which enzymes function to maintain genetic information stored in chromosomes. Projects in the laboratory focus on DNA strand invasion and strand exchange during the process of homologous recombination. A universally conserved pathway organisms use to maintain their chromosomes. Our laboratory uses a combination of biochemical, biophysical, and genetic approaches as we seek to develop high resolution models.
Crickard JB Discrete roles for Rad54 and Rdh54 during homologous recombination. (2021) Current Opinion in Genetics & Development PMID: 34293661
Crickard JB, Kwon Y, Sung P, Greene EC Rad54 and Rdh54 occupy spatially and functionally distinct sites within the Rad51-ssDNA presynaptic complex. (2020) EMBO J PMID: 32790929
Crickard JB, Moevus CJ, Kwon Y, Sung P, Greene EC. Rad54 drives ATP-hydrolysis dependent DNA sequence alignment during homologous recombination (2020) Cell. PMID: 32502392
Awards & Honors
2017-2020 Damon Runyon Cancer Research Foundation Fellow
Brooks teaches BIOMG 3350 an introductory biochemistry course. His current goals are to improve his ability to teach enzymatic reaction mechanisms to undergraduates, including improved methods for teaching enzyme kinetics.
259 Biotechnology Building
Ithaca, NY 14853
jbc287 [at] cornell.edu
Brooks in the news
Margaret Keymakh ’23 remembers well the day when her assays starting returning the results she was hoping for – and how excited she was when her replications of those experiments corroborated those findings. “I was doing this experiment getting...
- Molecular Biology and Genetics