Elizabeth Kellogg

My lab studies the mechanisms of molecular innovation. Transposons are an evolutionary driving force that reshape genomes, and we study how these genetic elements function as well as how to re-engineer them using computational protein engineering. We are particularly interested in elements that are capable of regulating their activity. In particular, we are highly interested in CRISPR-associated transposons which are capable of directing their DNA-insertions that is dependent on guide-RNA sequence. We use cryo-electron microscopy alongside other tools to understand how these transposons evolve and function in order to repurposethese elements for genome-editing applications.

Selected Publications

• Park J.P., Tsai A.W.T., Mehrotra, E., PetassiM.T., Hsieh S-C., Ke A., Peters J.E., Kellogg E.H. “Structural Basis of Target Site Selection in RNA-guided transposition systems”. Science, July 15, 2021. doi: 10.1126/science.abi8976
• Cianfrocco M.A. and Kellogg E.H. “What could go wrong? A practical guide to single-particle cryo-EM: From Biochemistry to Atomic Models” J. Chem. Inf. Model. 2020
• Ghanim G.*, Kellogg EH.*#, Nogales E., and Rio DC. # “Cryo-EM structure of the P element transposase strand transfer complex” Nature Struct. Mol. Biol. 2019
• Kellogg EH.*, Hejab N*, Poepsel S., Downing KH, Dimaio F., and Nogales E. “Near-atomic cryo-EM reconstruction of microtubule-tau interactions” Science360(6394):1242-46, June 2018
• Kellogg EH, Leaver-Fay A., Baker D., “Role of conformational sampling in computing mutation-induced changes in protein structure and stability” Proteins: Structure, Function, Bioinformatics.29(3):830-8, 2011

• Robert N. Noyce Assistant Professor in Life Science and Technology 2022
• American Crystallographic Society, Cryo-EM Interest Group Chair 2022
• Pew Biomedical Scholars 2021
• Rita Allen Scholar 2021 (declined)

• BIOG 4990: Independent Undergraduate Research in Biology