Jingyue (Ellie) Duan
Assistant Professor, Animal Science
Our research group uses genomics and computational approaches to investigate key molecular mechanisms which regulate transcription events in animal developmental reprogramming. We identify functional factors that coordinate gene expression during development and under environmental stressors. Our long-term goal is to understand epigenetic mechanisms in animal health and disease and use functional genomics tools to improve animal fertility and health.
Research Interests:
- Investigation of chromosome-wide epigenetic regulation on X chromosome dosage compensation
- Identification of mechanisms which drive coordinated transcription activation during development
- Define the effect of parental and environmental stressors on epigenetic reprogramming
Education
- Postdoctoral
Genetics and Genomics, Brown University - 2021 - Doctorate
Animal Epigenetics, University of Connecticut - 2018 - Bachelor of Science
Biology and life science, Sichuan University - 2014
Recent Research
1. Duan JE*, Rieder L*, Colonnetta M, Huang A, Mckenney M, Watters S, Deshpande G, Jordan W, Fawzi N, Larschan E. (2021) CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic genome activation. eLife DOI: 10.7554/eLife.69937
2. Duan J and Larschan E. (2019) Dosage Compensation: How to Be Compensated…Or Not? Current Biology. https://doi.org/10.1016/j.cub.2019.09.065
3. Duan JE, Jiang Z, Alqahtani F, Mandoiu I, Dong H, Zheng X, Marjani S, Chen J and Tian XC. (2019) Whole genome bisulfite sequencing of bovine in vivo gametes and preimplantation embryos. Frontier of Genetics doi: 10.3389/fgene.2019.00512
4. Duan JE, Flock K, Jue N, Zhang M, Jones A, Seesi S, Mandoiu I, Pillai S, Hoffman M, O’Neill R, Zinn S, Govoni K, Reed S, Jiang H, Jiang Z and Tian XC. (2019) Dosage Compensation and Gene Expression of the X Chromosome in Sheep. G3: Genes Genomes Genetics https://doi.org/10.1534/g3.118.200815 selected to publish in GSA Journal Spotlight 2019
5. Duan JE, Jue NK, Jiang Z, O’Neill R, Wolf E, Blomberg LA, Talbot N, Dong H, Zheng X, Chen J, and Tian XC. (2019) Dosage compensatory of X chromosome in bovine germline cells, early developmental embryos and somatic cells. Genome Biology and Evolution doi: 10.1093/gbe/evy270
6. Duan JE, Zhu L, Dong H, Zheng X, Chen J, Jiang Z, and X. Tian. (2019) Abundance of mRNA for histone variants, histone, and DNA modification enzymes in bovine in vivo oocytes and pre-implantation embryos. Scientific Reports doi: 10.1038/s41598-018-38083-4
7. Duan JE, Zhang M, Flock K, Seesi S, Mandoiu I, Jones A, Johnson E, Pillai S, Hoffman M, Mcfadden K, Jiang H, Reed S, Govoni K, Zinn S, Jiang Z and Tian XC (2018). Effects of Maternal Nutrition on the Expression of Genomic Imprinted genes in Ovine Fetuses. Epigenetics doi: 10.1080/15592294.2018.1503489
8. Jiang Z, Lin J, Dong H, Zheng X, Marjani SL, Duan JE, Ouyang Z, Chen J, and Tian XC. (2018) DNA methylomes of bovine gametes and in vivo produced preimplantation embryos. Biology of Reproduction doi:10.1093/biolre/ioy138
9. Wang L, Jiang Z, Huang D, Duan J, Huang C, Sullivan S, Vali K, Yin Y, Zhang M, Wegrzyn J, Tian XC, and Tang Y (2018) JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process. BMC Genomics 19:183 doi:10.1186/s12864-018-4507-2
10. Huang D, Wang L, Duan J, Huang C, Tian XC, Zhang M, and Tang Y (2018) LIF-activated Jak signaling determines Esrrb expression during late-stage reprogramming. Biology Open doi:10.1242/bio.029264
11. Wen W, Luo X, Xia B, Guan J, Nie Y, Li L, Duan J, Suman SP, and Sun Q. (2015) Post-mortem oxidative stability of three yak (Bos grunniens) muscles as influenced by animal age. Meat science doi: 10.1016/j.meatsci.2015.03.014.
12. Feng Q, Jing Y, Huang Z, Duan J, Zhen C, Sun H, Zhong J, and Sun Q. (2014) Genotyping of Beijing family of Mycobacterium tuberculosis isolates from Sichuan with MIRU-VNTR. Journal of Sichuan University (Medical Science Edition) doi: 103969/j.issn.0490 6756.2014.04.036
Contact Information
258 Morrison Hall
Ithaca, NY 14853
jd774 [at] cornell.edu
Jingyue (Ellie) in the news
News
- PRO-DAIRY
- Animal Science
- Animals
News
Research involving animal models – for purposes such as developing new vaccines or regenerative medicines – generally employ mice, but new Cornell research has identified another species that could be valuable in this type of work.
- Animal Science
- Genetics
- Microbiology