Our research group uses genomics and computational approaches to investigate key molecular mechanisms which regulate transcription events in animal developmental reprogramming. We identify functional factors that coordinate gene expression during development and under environmental stressors. Our long-term goal is to understand epigenetic mechanisms in animal health and disease and use functional genomics tools to improve animal fertility and health.
Investigation of chromosome-wide epigenetic regulation on X chromosome dosage compensation
Identification of mechanisms which drive coordinated transcription activation during development
Define the effect of parental and environmental stressors on epigenetic reprogramming
Postdoctoral Genetics and Genomics, Brown University - 2021
Doctorate Animal Epigenetics, University of Connecticut - 2018
Bachelor of Science Biology and life science, Sichuan University - 2014
1.Duan JE*, Rieder L*, Colonnetta M, Huang A, Mckenney M, Watters S, Deshpande G, Jordan W, Fawzi N, Larschan E. (2021) CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic genome activation. eLife DOI: 10.7554/eLife.69937 2.Duan Jand Larschan E. (2019) Dosage Compensation: How to Be Compensated…Or Not? Current Biology. https://doi.org/10.1016/j.cub.2019.09.065 3.Duan JE, Jiang Z, Alqahtani F, Mandoiu I, Dong H, Zheng X, Marjani S, Chen J and Tian XC. (2019) Whole genome bisulfite sequencing of bovine in vivo gametes and preimplantation embryos. Frontier of Genetics doi: 10.3389/fgene.2019.00512
4.Duan JE, Flock K, Jue N, Zhang M, Jones A, Seesi S, Mandoiu I, Pillai S, Hoffman M, O’Neill R, Zinn S, Govoni K, Reed S, Jiang H, Jiang Z and Tian XC. (2019) Dosage Compensation and Gene Expression of the X Chromosome in Sheep. G3: Genes Genomes Geneticshttps://doi.org/10.1534/g3.118.200815 selected to publish in GSA Journal Spotlight 2019
5.Duan JE, Jue NK, Jiang Z, O’Neill R, Wolf E, Blomberg LA, Talbot N, Dong H, Zheng X, Chen J, and Tian XC. (2019) Dosage compensatory of X chromosome in bovine germline cells, early developmental embryos and somatic cells. Genome Biology and Evolutiondoi: 10.1093/gbe/evy270 6.Duan JE, Zhu L,Dong H, Zheng X, Chen J, Jiang Z, and X. Tian. (2019) Abundance of mRNA for histone variants, histone, and DNA modification enzymes in bovine in vivo oocytes and pre-implantation embryos. Scientific Reportsdoi: 10.1038/s41598-018-38083-4 7.Duan JE, Zhang M, Flock K, Seesi S, Mandoiu I, Jones A, Johnson E, Pillai S, Hoffman M, Mcfadden K, Jiang H, Reed S, Govoni K, Zinn S, Jiang Z and Tian XC (2018). Effects of Maternal Nutrition on the Expression of Genomic Imprinted genes in Ovine Fetuses. Epigeneticsdoi: 10.1080/15592294.2018.1503489 8.Jiang Z, Lin J, Dong H, Zheng X, Marjani SL, Duan JE, Ouyang Z, Chen J, and Tian XC. (2018) DNA methylomes of bovine gametes and in vivo produced preimplantation embryos.Biology of Reproductiondoi:10.1093/biolre/ioy138 9.Wang L, Jiang Z, Huang D, Duan J, Huang C, Sullivan S, Vali K, Yin Y, Zhang M, Wegrzyn J, Tian XC, and Tang Y (2018) JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process. BMC Genomics19:183 doi:10.1186/s12864-018-4507-2 10.Huang D, Wang L, Duan J, Huang C, Tian XC, Zhang M, and Tang Y (2018) LIF-activated Jak signaling determines Esrrb expression during late-stage reprogramming. Biology Open doi:10.1242/bio.029264 11.Wen W, Luo X, Xia B, Guan J, Nie Y, Li L, DuanJ, Suman SP, and Sun Q. (2015) Post-mortem oxidative stability of three yak (Bos grunniens) muscles as influenced by animal age. Meat sciencedoi: 10.1016/j.meatsci.2015.03.014. 12.Feng Q, Jing Y, Huang Z, DuanJ, Zhen C, Sun H, Zhong J, and Sun Q. (2014) Genotyping of Beijing family of Mycobacterium tuberculosis isolates from Sichuan with MIRU-VNTR.Journal of Sichuan University (Medical Science Edition)doi: 103969/j.issn.0490 6756.2014.04.036
Academic focus: My academic focus is in understanding how epigenetics drives embryonic reprogramming, X chromosome dosage compensation, genetic imprinting and heat-induced responses. Research summary: Our research group uses genomics and...