Associate Professor, Department of Entomology
My research focuses on the impact of pathogens and the microbiota on body homeostasis. We use systemic infection as a model for septicemia, and the gut response to infection as a model for mucosal immunity. Genomic and genetic approaches allow us to characterize new pathways involved in both resistance and tolerance to infection. Specifically, we are interested in the three-way dialogue between gut microbes, intestinal stem cells, and gut structure and function.
My laboratory focuses on the genetic and cellular mechanisms that maintain tissue homeostasis in response to pathogens and the microbiota. I established my lab at Cornell University in 2012 and work in my lab integrates multiple aspects of host-microbe interactions, including the regulation of immune pathways and the microbial signals that modulate them, the differential impacts of microbiota and pathogens (bacterial and viral) on host homeostasis and the cross-talk between infection and host physiology. My lab has particularly focused on the impact of microbes, pathogenic or not on the activity of intestinal stem cells, both as a model of tissue repair, and as a way to dissect how a microbiome interacts with its host. My group's research includes an integrative approach to the role of microbes on tissue homeostasis that incorporates functional genetics in both the host and the microbe, with genomics, transcriptomics, and systems level approaches both in genetic models (Drosophila, mouse) and non-model organisms (for instance the mosquito Aedes aegypti, an important disease vector).
I teach two primary courses. First I am an instructor in BioG1440, "Comparative Physiology", which aims to introduce key physiological concepts to students. In addition, I teach Entom4830 "Insect physiology" which focuses on the mechanisms underlying how insects work.
- Troha, K., Im, J. H., Revah, J., Lazzaro, B. P., & Buchon, N. (2018). Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster. PLoS Pathogens. 14:e1006847.
- Inamine, H., Ellner, S. P., Newell, P. D., Luo, Y., Buchon, N., & Douglas, A. E. (2018). Spatiotemporally Heterogeneous Population Dynamics of Gut Bacteria Inferred from Fecal Time Series Data. mBio. 9:17.
- Sun, H., Buchon, N., & Scott, J. G. (2017). Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster. Insect Biochemistry and Molecular Biology. 89:11-16.
- Liu, X., Hodgson, J. J., & Buchon, N. (2017). Drosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gut. PLoS Pathogens. 13:e1006277.
- Buchon, N., & Osman, D. (2015). All for one and one for all: Regionalization of the Drosophila intestine. Insect Biochemistry and Molecular Biology.
- Sansone, C. L., Cohen, J., Yasunaga, A., Xu, J., Osborn, G., Subramanian, H., Gold, B., Buchon, N., & Cherry, S. (2015). Microbiota-Dependent Priming of Antiviral Intestinal Immunity in Drosophila. Cell Host & Microbe.
- Dutta, D., Buchon, N., Xiang, J., & Edgar, B. A. (2015). Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations. Current Protocols in Stem Cell Biology.
- Dutta, D., Dobson, A. J., Houtz, P. L., Gläßer, C., Revah, J., Korzelius, J., Patel, P. H., Edgar, B. A., & Buchon, N. (2015). Regional Cell Specific RNA Expression Profiling of FACS Isolated Drosophila Intestinal Cell Populations. Cell Reports.
- Xiao, H., wang, H., Silva , E. A., Thompson, J., Guillou, A., Yates Jr, J. R., Buchon, N., & Franc, N. C. (2015). The Pallbearer E3 ligase promotes actin remodeling via RAC in efferocytosis by degrading the ribosomal protein S6. Developmental Cell.
- Buchon, N., Silverman, N., & Cherry, S. (2014). Immunity in Drosophila melanogaster--from microbial recognition to whole-organism physiology. Nature Reviews Immuno.
5124 Comstock Hall
nicolas.buchon [at] cornell.edu
Nicolas in the news
A new study of the common fruit fly (Drosophila melanogaster) has identified a protein in the male’s seminal fluid that triggers the female’s midgut to expand after mating. This widening and lengthening of the gut likely prepares the female for...
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