Assistant Professor, Molecular Biology and Genetics
Dr. Martin Graef is an Assistant Professor in the Department of Molecular Biology and Genetics and a member of the Graduate Field of Genetics, Genomics and Development and the Graduate Field of Biochemistry, Molecular and Cell Biology. The Graef lab studies the molecular mechanisms and physiological functions of autophagy and cellular ageing with links to human disease. They focus on the interplay of autophagy with lipid and membrane biology, mitochondria behavior and function, and genome maintenance. To address these fundamental questions, the Graef lab uses biochemistry, state-of-the-art live cell imaging, and system-wide genetics and proteomics approaches towards building quantitative models for yeast and mammalian cells.
- Schütter M, Giavalisco P, Brodesser S, and Graef M (2020). Local fatty acid channeling into phospholipidsynthesis drives phagophore expansion during autophagy. Cell 180, 135-149.
- Medeiros TC, Thomas RL, Ghillebert R, Graef M (2018). Autophagy balances DNA synthesis and degradation by mtDNA polymerase POLG during starvation. J. Cell Biol. 217, 1601-1611.
- Velázquez AP, Tatsuta T, Ghillebert R, Drescher I, and Graef M (2016). Lipid droplet- mediated ER homeostasis regulates autophagy and cell survival during starvation. J. Cell Biol. 212, 621-631.
Ithaca, NY 14853
mg2255 [at] cornell.edu